Genomes and evolution Population genetics and molecular evolution of whole genomes.
نویسندگان
چکیده
Andrew Clark’s laboratory works on molecular population genetics in Drosophila and in humans. The Drosophila systems include an analysis of genetic variation responsible for variation and interspecific divergence in sperm competition, bacterial resistance, and in flight metabolism. His lab has also been instrumental in the discovery and analysis of genes on the Drosophila Y chromosome. His work in human genetics centers on methods for testing association between genotypic and phenotypic variation in complex traits, with an emphasis on cardiovascular disease.
منابع مشابه
Predicting CpG Islands and Their Relationship with Genomic Feature in Cattle by Hidden Markov Model Algorithm
Cattle supply an important source of nutrition for humans in the world. CpG islands (CGIs) are very important and useful, as they carry functionally relevant epigenetic loci for whole genome studies. As a matter of fact, there have been no formal analyses of CGIs at the DNA sequence level in cattle genomes and therefore this study was carried out to fill the gap. We used hidden markov model alg...
متن کاملEvolution at the nucleotide level: the problem of multiple whole-genome alignment.
With the genome sequences of numerous species at hand, we have the opportunity to discover how evolution has acted at each and every nucleotide in our genome. To this end, we must identify sets of nucleotides that have descended from a common ancestral nucleotide. The problem of identifying evolutionary-related nucleotides is that of sequence alignment. When the sequences under consideration ar...
متن کاملThe evolution of plant genomes: scaling up from a population perspective.
Plant genomes exhibit tremendous diversity in both their size and structure, with genome sizes across land plants ranging over two to three orders of magnitude and significant variation in structural organization was observed across species (EA Kellogg, JL Bennetzen, The evolution of nuclear genome structure in seed plants, Am J Bot 2004, 91:1709-1725). Five plant genomes are now either complet...
متن کاملApplications of the 1000 Genomes Project resources
The 1000 Genomes Project created a valuable, worldwide reference for human genetic variation. Common uses of the 1000 Genomes dataset include genotype imputation supporting Genome-wide Association Studies, mapping expression Quantitative Trait Loci, filtering non-pathogenic variants from exome, whole genome and cancer genome sequencing projects, and genetic analysis of population structure and ...
متن کاملThe Human Molecular Clock and Mutation Process: A Characterization Using Microsatellite DNA
In the past decade, thousands of human genomes have been catalogued, either by whole-genome sequencing or by targeted genotyping. The variability between human genomes encodes invaluable information about human traits and genetic diseases, as well as human migration patterns and population interactions. A key challenge is to understand and characterize the evolution of the variability between h...
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عنوان ژورنال:
- Current opinion in genetics & development
دوره 12 6 شماره
صفحات -
تاریخ انتشار 2002